Since Fallout 4 has proper Remote Play controls, check out the new trailer

Yes, its not a PS Vita, but get used to this! Since PlayStation Now and Remote Play let us play big name games on your handheld, that's pretty much its future.

The good news is, the developers are taking care to ensure a decent Remote Play experience, when it comes to controls (your WiFi may limit other aspects).
So, enjoy the trailer and get ready to cough up for a PS4 if you really want to make your Vita a part of your gaming family beyond 2016.